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KMID : 0861020200350020047
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Korea Journal of Herbology
2020 Volume.35 No. 2 p.47 ~ p.53
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Effects of a Two-Week-Oral-Toxicity Study ofBombyx batryticatus L. Extracts on C57BL/6 Mice
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Nam Hyeon-Hwa
Seo Yun-Soo
Moon Byeong-Cheol
Lee Ji-Hye
Kim Yong-Bum
Kim Joong-Sun
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Abstract
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Objectives : Bombyx batryticatus L. is the dried larval form of the silkworm (Bombyx mori L.) infected by Beauveria bassiania (Bals.) Vuill. It is used as a food and medicinal resource to treat asthma, headaches, epilepsy, and convulsions in traditional Korean and Chinese medicines. However, the research of the toxicity about B. batryticatus is not enough yet. Here, we investigate the effects of potential subacute toxicity following the repeated oral administration of B. batryticatus water extract to C57BL/6 mice, at various doses of 0, 50, 150, and 450 ㎎/㎏/day during a two-week period.
Methods : The following parameters were examined during the study period: body weight, gross findings, clinical signs, organ weight, hematology, serum biochemistry, histopathology, and mortality. At the end of the treatment period, all the mice were euthanized.
Results : No changes were observed in the body weights, gross findings, clinical signs, organ weights, and mortality after two weeks of administration of the B. batryticatus extract. In addition, compared with the normal control group, no noticeable treatment-related changes were observed in the hematological, serum biochemical, and histopathological parameters in the treated group following treatment with doses of up to 450 ㎎/㎏/day.
Conclusion : Based on these findings, we conclude that the treatment of mice with the water extract of B. batryticatus did not cause considerable C57BL/6 toxicity, and therefore, it could be considered safe for further pharmacological studies.
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KEYWORD
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Bombyx batryticatus, insect, Two-Week-Oral-Toxicity Study
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